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Molecular mechanisms of cardiac disease:
Translating insights into new diagnostic tools and therapies

Cardiovascular diseases, such as heart failure, cardiac arrhythmias, congenital heart disorders, and vascular diseases, are the leading causes of morbidity and mortality in adults and children throughout the world.

The overall goals of our research program are to gain insights into the molecular mechanisms of these cardiovascular diseases as well as discover developmental pathways that help create the cardiovascular system. We are most interested in translating these findings for eventual cardiac therapies and early diagnostic tools, including cardiac regenerative cellular repair, gene therapies, and genetic/genomic testing.

Towards this end, our laboratory uses a combination of human cardiovascular patients and their samples derived from UC San Diego's Sulpizio Cardiovascular Center as well as various model organisms, such as zebrafish, newts, and mice, for our investigations.