Featured Publications

Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension

Laffin LJ, Kopjar B, Melgaard C, Wolski K, Ibbitson J, Bhikam S, Weir MR, Ofili EO, Mehra R, Luther JM, Cohen DL, Sarraju A, Wilkinson MJ, Flack JM, Rodman D, Nissen SE; Advance-HTN Investigators. Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension. N Engl J Med. 2025 Apr 23. doi: 10.1056/NEJMoa2501440. Epub ahead of print. PMID: 40267417.

Preclinical efficacy and safety of AAVrh10-based plakophilin-2 gene therapy (LX2020) as a treatment for arrhythmogenic cardiomyopathy

Zhang J, Gutierrez-Lara EJ, Do A, Nguyen L, Nair A, Selvan N, Fenn T, Adler E, Khanna R, Sheikh F. Preclinical efficacy and safety of AAVrh10-based plakophilin-2 gene therapy (LX2020) as a treatment for arrhythmogenic cardiomyopathy. NPJ Regen Med. 2025 Apr 3;10(1):17. doi: 10.1038/s41536-025-00401-6. PMID: 40175378; PMCID: PMC11965304.

Patient Characteristics and Outcomes of Radial to Femoral Access-Site Crossover

Revathy Sampath-Kumar, MD ∙ Ehtisham Mahmud, MD ∙ Kerem Korkmaz ∙ Lawrence Ang, MD ∙ Belal Al Khiami, MD ∙ Anna Melendez, MSN, RN ∙ Ryan Reeves, MD ∙ Ori Ben-Yehuda, MD.
Patient Characteristics and Outcomes of Radial to Femoral Access-Site Crossover
Journal of the Society for Cardiovascular Angiography & Interventions, Volume 4, Issue 1, 102450
DOI: 10.1016/j.jscai.2024.102450

Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol–Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis

Bhatia, H. S., Wandel, S., Willeit, P., Lesogor, A., Bailey, K., Ridker, P. M., Nestel, P., Simes, J., Tonkin, A., Schwartz, G. G., Colhoun, H., Wanner, C., & Tsimikas, S. (2024). Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis. Circulation, 10.1161/CIRCULATIONAHA.124.069556. Advance online publication. https://doi.org/10.1161/CIRCULATIONAHA.124.069556

Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease

Greenberg, B., Taylor, M., Adler, E., Colan, S., Ricks, D., Yarabe, P., Battiprolu, P., Shah, G., Patel, K., Coggins, M., Carou-Keenan, S., Schwartz, J. D., & Rossano, J. W. (2024). Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease. The New England journal of medicine, 10.1056/NEJMoa2412392. Advance online publication. https://doi.org/10.1056/NEJMoa2412392

Automated Breast Arterial Calcification Score Is Associated With Cardiovascular Outcomes and Mortality

Allen, T. S., Bui, Q. M., Petersen, G. M., Mantey, R., Wang, J., Nerlekar, N., Eghtedari, M., & Daniels, L. B. (2024). Automated Breast Arterial Calcification Score Is Associated With Cardiovascular Outcomes and Mortality. JACC. Advances, 3(11), 101283. https://doi.org/10.1016/j.jacadv.2024.101283

Time-Restricted Eating in Adults With Metabolic Syndrome: A Randomized Controlled Trial

Manoogian ENC, Wilkinson MJ, O'Neal M, Laing K, Nguyen J, Van D, Rosander A, Pazargadi A, Gutierrez NR, Fleischer JG, Golshan S, Panda S, Taub PR. Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial. Ann Intern Med. 2024 Oct 1. doi: 10.7326/M24-0859. Epub ahead of print. PMID: 39348690.

Sex Differences in Characteristics, Resource Utilization, and Outcomes of Cardiogenic Shock: Data From the Critical Care Cardiology Trials Network (CCCTN) Registry

Daniels LB, Phreaner N, Berg DD, Bohula EA, Chaudhry SP, Fordyce CB, Goldfarb MJ, Katz JN, Kenigsberg BB, Lawler PR, Martillo Correa MA, Papolos AI, Roswell RO, Sinha SS, van Diepen S, Park JG, Morrow DA; Critical Care Cardiology Trials Network Investigators. Sex Differences in Characteristics, Resource Utilization, and Outcomes of Cardiogenic Shock: Data From the Critical Care Cardiology Trials Network (CCCTN) Registry. Circ Cardiovasc Qual Outcomes. 2024 Jun 20:e010614. doi: 10.1161/CIRCOUTCOMES.123.010614. Epub ahead of print. PMID: 38899459.

Natural history and clinical outcomes of patients with hypertrophic cardiomyopathy from thin filament mutations

Saul T, Bui QM, Argiro A, Keyt L, Olivotto I, Adler E. Natural history and clinical outcomes of patients with hypertrophic cardiomyopathy from thin filament mutations. ESC Heart Fail. 2024 May 21. doi: 10.1002/ehf2.14848. Epub ahead of print. PMID: 38773858.

Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome

Stroes ESG, Alexander VJ, Karwatowska-Prokopczuk E, Hegele RA, Arca M, Ballantyne CM, Soran H, Prohaska TA, Xia S, Ginsberg HN, Witztum JL, Tsimikas S; Balance Investigators. Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome. N Engl J Med. 2024 May 16;390(19):1781-1792. doi: 10.1056/NEJMoa2400201. Epub 2024 Apr 7. PMID: 38587247.

Spatially organized cellular communities form the developing human heart

Farah EN, Hu RK, Kern C, Zhang Q, Lu TY, Ma Q, Tran S, Zhang B, Carlin D, Monell A, Blair AP, Wang Z, Eschbach J, Li B, Destici E, Ren B, Evans SM, Chen S, Zhu Q, Chi NC. Spatially organized cellular communities form the developing human heart. Nature. 2024 Mar;627(8005):854-864. doi: 10.1038/s41586-024-07171-z. Epub 2024 Mar 13. PMID: 38480880; PMCID: PMC10972757.

Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support The STOP-RVF Score

Taleb I, Kyriakopoulos CP, Fong R, Ijaz N, Demertzis Z, Sideris K, Wever-Pinzon O, Koliopoulou AG, Bonios MJ, Shad R, Peruri A, Hanff TC, Dranow E, Giannouchos TV, Krauspe E, Zakka C, Tang DG, Nemeh HW, Stehlik J, Fang JC, Selzman CH, Alharethi R, Caine WT, Cowger JA, Hiesinger W, Shah P, Drakos SG. Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support: The STOP-RVF Score. JAMA Cardiol. 2024 Jan 31:e235372. doi: 10.1001/jamacardio.2023.5372. Epub ahead of print. PMID: 38294795; PMCID: PMC10831631.

Aspirin and Cardiovascular Risk in Individuals With Elevated Lipoprotein(a): The Multi‐Ethnic Study of Atherosclerosis

Bhatia HS, Trainor P, Carlisle S, Tsai MY, Criqui MH, DeFilippis A, Tsimikas S. Aspirin and Cardiovascular Risk in Individuals With Elevated Lipoprotein(a): The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2024 Feb 6;13(3):e033562. doi: 10.1161/JAHA.123.033562. Epub 2024 Jan 31. PMID: 38293935.

Inferior vena cava diameter and risk of acute decompensated heart failure rehospitalisations

Sampath-Kumar R, Ben-Yehuda O. Inferior vena cava diameter and risk of acute decompensated heart failure rehospitalisations. Open Heart. 2023 Sep;10(2):e002331. doi: 10.1136/openhrt-2023-002331. PMID: 37696618; PMCID: PMC10496688.

Global longitudinal strain predicts clinical outcomes in patients with heart failure with preserved ejection fraction

Brann A, Miller J, Eshraghian E, Park JJ, Greenberg B. Global longitudinal strain predicts clinical outcomes in patients with heart failure with preserved ejection fraction. Eur J Heart Fail. 2023 Jun 27. doi: 10.1002/ejhf.2947. Epub ahead of print. PMID: 37369633.

In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation Registry

Darden D, Aldaas O, Du C, Munir MB, Feld GK, Pothineni NVK, Gopinathannair R, Lakkireddy D, Curtis JP, Freeman JV, Akar JG, Hsu JC. In-hospital complications associated with pulmonary vein isolation with adjunctive lesions: the NCDR AFib Ablation Registry. Europace. 2023 May 15;25(5):euad124. doi: 10.1093/europace/euad124. Epub ahead of print. PMID: 37184436; PMCID: PMC10228609.

Coronary Artery Calcium Density and Cardiovascular Events by Volume Level: The MESA

Bhatia HS, McClelland RL, Denenberg J, Budoff MJ, Allison MA, Criqui MH. Coronary Artery Calcium Density and Cardiovascular Events by Volume Level: The MESA. Circ Cardiovasc Imaging. 2023 Feb;16(2):e014788. doi: 10.1161/CIRCIMAGING.122.014788. Epub 2023 Feb 21. PMID: 36802448; PMCID: PMC10191167.

Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures

Hsu JC, Darden D, Du C, Marine JE, Nichols S, Marcus GM, Natale A, Noseworthy PA, Selzman KA, Varosy P, Masoudi F, Freeman J, Curtis J, Akar J, Kowey PR. Initial Findings From the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures. J Am Coll Cardiol. 2023 Mar 7;81(9):867-878. doi: 10.1016/j.jacc.2022.11.060. PMID: 36858707.

Trends in LDL-C following coronary angiography involving assessment by fractional flow reserve in obstructive vs non-obstructive coronary artery disease

Wilkinson MJ, Xu I, Vasudevan RS, You H, Xu R, Taub PR. Trends in LDL-C following coronary angiography involving assessment by fractional flow reserve in obstructive vs non-obstructive coronary artery disease. Am J Prev Cardiol. 2023 Feb 13;13:100473. doi: 10.1016/j.ajpc.2023.100473. PMID: 36865903; PMCID: PMC9971059.

Priorities and Understanding of Pregnancy Among Women With Congenital Heart Disease: A Mixed-Methods Study

Citation: Herrick N, Al-Rousan T, Rodriguez C, et al. Priorities and Understanding of Pregnancy Among Women With Congenital Heart Disease. JACC Adv. 2022 Oct, 1 (4) 1–10.https://doi.org/10.1016/j.jacadv.2022.100112

Authors: Nicole Herrick, MD Tala Al-Rousan, MD, MPH Carla Rodriguez, MD Ji Hae Lee, BA Anne Marie Valente, MD Jordan Stone, MD Gladys Ramos, MD Bendelyn Asante-Boateng, MD Howaida El-Said, MD, PhD Maria Moceri-Casas, RN, BSN Laith Alshawabkeh, MD, MSCI

Forward-Solution Noninvasive Computational Arrhythmia Mapping: The VMAP Study

Krummen DE, Villongco CT, Ho G, Schricker AA, Field ME, Sung K, Kacena KA, Martinson MS, Hoffmayer KS, Hsu JC, Raissi F, Feld GK, McCulloch AD, Han FT. Forward-Solution Noninvasive Computational Arrhythmia Mapping: The VMAP Study. Circ Arrhythm Electrophysiol. 2022 Sep;15(9):e010857. doi: 10.1161/CIRCEP.122.010857. Epub 2022 Sep 7. PMID: 36069189; PMCID: PMC9509662.