The Seaweed Canyon Cardiovascular Physiology Laboratory

Seaweed Cardiovascular Physiology Core Services

(Not limited to the following)

1. Invasive left heart and right heart functions and pathological cardiac models studies:

• • Hemodynamics with or without pressure volume loops studies with various agents' injections. 
  • Blood pressure measurement in conscience mice with telemetry, in anesthetized mice with catheters.
  • Electrocardiogram (ECG) in conscience mice using telemetry, or under anesthetized with isoflurane
  • Intra-cardiac pacing with electric programming stimulation
  • Transverse aortic constriction (TAC) and post TAC pressure gradient measurements
  • Myocardial infarction
  • Ischemia reperfusion
  • Mini pump implantation
  • Neonatal mice apex resection
  • Aortic stenosis wire injury
  • Intra- cardiac, ventricles and venous injections of virus, cells or experiment agents.
  • Blood and tissue collections

       2.     Non-invasive cardiac function studies:

• •  Echocardiography: 
    
    • Pulsed-Wave Doppler (aortic flow and pulmonary flow)
    • 2D (chamber size and function, aortic arch size)
    • 4 Chamber view with Pulsed-Wave Doppler and Tissue Doppler
    • Strain Analysis
  • Other measurements

• • • Tail cuff
    • Treadmill

Directors

Dr. Eric D. Adler and Dr. Ju Chen, Co-Directors, 2020-present

Dr. Kirk L. Peterson, Associate Director, 1988 – 2005, and Director, 2005-2020

Dr. John Ross, Jr., Director, 1972 - 2005

Dr. Eugene Braunwald, Director, 1968 - 1972

Dr. Dean Franklin, Founding Director, 1965-1970