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Adult Congenital Heart Disease Research

  1. Characteristics of left ventricular dysfunction in repaired tetralogy of Fallot: A multi-institutional deep learning analysis of regional strain and dyssynchrony
    Crabb BT, Chandrupatla RS, Masutani EM, Wong SY, Govil S, Montserrat S, Prat-González S, Vega-Adauy J, Atkins M, Lorenzatti D, Zocchi C, Panaioli E, Boddaert N, Alshawabkeh L, Hahn L, Hegde S, McCulloch AD, Raimondi F, Hsiao A.
    J Cardiovasc Magn Reson. 2025 Summer;27(1):101886. doi: 10.1016/j.jocmr.2025.101886. Epub 2025 Mar 21.

  2. Single-center perioperative management and 1-year heart transplantation outcomes for patients with adult congenital heart disease
    Robinson R, Gaboyan S, Alshawabkeh L, Reeves R, Golts E, Pretorius V, Nigro J, Kearns M, El-Said H, Carazo M, Hong K, Adler E, Kim PJ, Topik A, Raleigh D, Meier A, Ellis S, Sanchez R, Afshar K, Kafi A, Lin C, Yung G, Brubaker A, Schnickel G, Mekeel K, Berumen J, Parekh J, Barman P, Ajmera V, Kono Y, Vodkin I, Urey MA.
    JHLT Open. 2025 Mar 7;8:100243. doi: 10.1016/j.jhlto.2025.100243. eCollection 2025 May.

  3. Patient comfort with sexual orientation and gender identity questions in adult congenital cardiology clinics
    Cook SC, Deb B, Pastor T, Hobson C, Walsh K, Ofner S, Salciccioli K, Gonzalez V, Reardon LC, Carazo M.
    Cardiol Young. 2024 Sep 13:1-8. doi: 10.1017/S1047951124025344. Online ahead of print.

  4. Medical Therapy for Heart Failure in Adult Congenital Heart Disease Patients
    Carazo M.
    Struct Heart. 2024 Apr 10;8(4):100297. doi: 10.1016/j.shj.2024.100297. eCollection 2024 Jul.

  5. Adults with Congenital Heart Disease and Transplant: Challenges, Opportunities, and Policy
    Herrick N, Urey M, Alshawabkeh L.
    Heart Fail Clin. 2024 Apr;20(2):167-174. doi: 10.1016/j.hfc.2023.12.009. Epub 2024 Jan 24.

  6. Frailty and Cognitive Function in Aging Adults With Congenital Heart Disease: A Lifetime of Limitations?
    Carazo MR.
    J Am Coll Cardiol. 2024 Mar 26;83(12):1160-1162. doi: 10.1016/j.jacc.2024.02.006.

  7. Corrigendum to 'The role of sensitization in post-transplant outcomes in adults with congenital heart disease sensitization in adults with congenital heart disease', Int. J. Cardiol. Congenit. Heart Dis., 8, June 2022, 100384
    Alshawabkeh L, Herrick NL, Opotowsky AR, Singh TP, Landzberg M, Urey MA, Cherikh W, Rossano JW, Givertz MM.
    Int J Cardiol Congenit Heart Dis. 2023 Nov 18;14:100474. doi: 10.1016/j.ijcchd.2023.100474. eCollection 2023 Dec.

  8. COVID-19-Related Thrombotic and Bleeding Events in Adults With Congenital Heart Disease
    Fusco F, Krasuski RA, Sadeghi S, Rosenbaum MS, Lewis MJ, Carazo MR, Rodriguez FH, Halpern DG, Feinberg JL, Galilea FA, Baraona F, Cedars AM, Ko JM, Porayette P, Maldonado JR, Frogoudaki AA, Nir A, Chaudhry A, John AS, Karbassi A, Ganame J, Hoskoppal A, Frischhertz BP, Hendrickson B, Rodriguez-Monserrate CP, Broda CR, Tobler D, Gregg D, Martinez-Quintana E, Yeung E, Krieger EV, Ruperti-Repilado FJ, Giannakoulas G, Lui GK, Ephrem G, Singh HS, Hasan A, Bartlett HL, Lindsay I, Grewal J, Nicolarsen J, Araujo JJ, Cramer JW, Bouchardy J, Al Najashi K, Ryan K, Alshawabkeh L, Andrade L, Ladouceur M, Schwerzmann M, Greutmann M, Merás P, Ferrero P, Dehghani P, Tung PP, Garcia-Orta R, Tompkins R, Gendi SM, Cohen S, Klewer SE, Hascoet S, Upadhyay S, Fisher SD, Cook S, Cotts TB, Kovacs AH, Aboulhosn JA, Scognamiglio G, Broberg CS, Sarubbi B.
    JACC Adv. 2023 Nov 21;2(10):100701. doi: 10.1016/j.jacadv.2023.100701. eCollection 2023 Dec.

  9. A case of double-chambered left ventricle presenting with heart failure symptoms
    Ahmad A, Carazo M.
    Cardiol Young. 2023 Jul;33(7):1196-1198. doi: 10.1017/S1047951122003614. Epub 2022 Nov 17.

  10. Morbidity and Mortality in Adult Fontan Patients After Heart or Combined Heart-Liver Transplantation
    Lewis MJ, Reardon LC, Aboulhosn J, Haeffele C, Chen S, Kim Y, Fuller S, Forbess L, Alshawabkeh L, Urey MA, Book WM, Rodriguez F 3rd, Menachem JN, Clark DE, Valente AM, Carazo M, Egbe A, Connolly HM, Krieger EV, Angiulo J, Cedars A, Ko J, Jacobsen RM, Earing MG, Cramer JW, Ermis P, Broda C, Nugaeva N, Ross H, Awerbach JD, Krasuski RA, Rosenbaum M.
    J Am Coll Cardiol. 2023 Jun 6;81(22):2161-2171. doi: 10.1016/j.jacc.2023.03.422.

  11. Clinical Outcomes of Adult Fontan-Associated Liver Disease and Combined Heart-Liver Transplantation
    Lewis MJ, Reardon LC, Aboulhosn J, Haeffele C, Chen S, Kim Y, Fuller S, Forbess L, Alshawabkeh L, Urey MA, Book WM, Rodriguez F 3rd, Menachem JN, Clark DE, Valente AM, Carazo M, Egbe A, Connolly HM, Krieger EV, Angiulo J, Cedars A, Ko J, Jacobsen RM, Earing MG, Cramer JW, Ermis P, Broda C, Nugaeva N, Ross H, Awerbach JD, Krasuski RA, Rosenbaum M.
    J Am Coll Cardiol. 2023 Jun 6;81(22):2149-2160. doi: 10.1016/j.jacc.2023.03.421.

  12. Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity
    Alotaibi M, Shao J, Pauciulo MW, Nichols WC, Hemnes AR, Malhotra A, Kim NH, Yuan JX, Fernandes T, Kerr KM, Alshawabkeh L, Desai AA, Bujor AM, Lafyatis R, Watrous JD, Long T, Cheng S, Chan SY, Jain M.
    Chest. 2023 Jan;163(1):204-215. doi: 10.1016/j.chest.2022.08.2230. Epub 2022 Sep 7.

  13. Priorities and Understanding of Pregnancy Among Women With Congenital Heart Disease: A Mixed-Methods Study
    Herrick N, Al-Rousan T, Rodriguez C, Lee JH, Valente AM, Stone J, Ramos G, Asante-Boateng B, El-Said H, Moceri-Casas M, Alshawabkeh L.
    JACC Adv. 2022 Oct 28;1(4):100112. doi: 10.1016/j.jacadv.2022.100112. eCollection 2022 Oct.

  14. Language Barriers in Patients With Cardiovascular Disease: A Mixed Methods Study
    Wang E, Al-Rousan T, Mansour W, Oliva D, Herrick N, Desai B, Alshawabkeh L.
    JACC Adv. 2022 Sep 21;1(4):100077. doi: 10.1016/j.jacadv.2022.100077. eCollection 2022 Oct.

  15. Transvenous laser lead extraction in patients with congenital complete heart block
    Darden D, Boateng BA, Tseng AS, Alshawabkeh L, Pollema T, Cha YM, Birgersdotter-Green U.
    Heart Rhythm. 2022 Jul;19(7):1158-1164. doi: 10.1016/j.hrthm.2022.02.031. Epub 2022 Mar 4.

  16. The role of sensitization in post-transplant outcomes in adults with congenital heart disease sensitization in adults with congenital heart disease
    Alshawabkeh L, Herrick NL, Opotowsky AR, Singh TP, Landzberg M, Urey MA, Cherikh W, Rossano JW, Givertz MM.
    Int J Cardiol Congenit Heart Dis. 2022 Apr 25;8:100384. doi: 10.1016/j.ijcchd.2022.100384. eCollection 2022 Jun.

  17. Selective Valve Removal for Melody Valve Endocarditis: Practice Variations in a Multicenter Experience
    Davtyan A, Guyon PW, El-Sabrout HR, Ponder R, Ramchandar N, Weber R, Zayed W, Ratnayaka K, Nigro JJ, Moore JW, Bauser-Heaton H, Alshawabkeh L, Reeves RR, Levi D, Aboulhosn J, Justino H, Bradley J, El-Said HG.
    Pediatr Cardiol. 2022 Apr;43(4):894-902. doi: 10.1007/s00246-021-02801-z. Epub 2021 Dec 11.

  18. Alcohol use is prevalent among adults with the fontan circulation but does not correlate with liver disease
    Chintakindi S, Boateng BA, Vodkin I, Herrick N, Moceri M, Raleigh D, Wang E, El-Said H, Reeves R, Sepulveda JS, Alshawabkeh L.
    Int J Cardiol Congenit Heart Dis. 2022 Jan 26;7:100339. doi: 10.1016/j.ijcchd.2022.100339. eCollection 2022 Mar.

  19. Epidemiology of cardiovascular disease and its risk factors among refugees and asylum seekers: Systematic review and meta-analysis
    Al-Rousan T, AlHeresh R, Saadi A, El-Sabrout H, Young M, Benmarhnia T, Han BH, Alshawabkeh L.
    Int J Cardiol Cardiovasc Risk Prev. 2022 Feb 10;12:200126. doi: 10.1016/j.ijcrp.2022.200126. eCollection 2022 Mar.

  20. Laparoscopic Surgery Requiring Abdominal Insufflation in Patients With Congenital Heart Disease
    Herrick NL, Bickler S, Maus T, Kim YY, Aboulhosn JA, Nigro J, El-Said H, Bhatt AB, Alshawabkeh L.
    J Cardiothorac Vasc Anesth. 2022 Mar;36(3):707-712. doi: 10.1053/j.jvca.2021.05.005. Epub 2021 May 12.

  21. Evidence of maternal vascular malperfusion in placentas of women with congenital heart disease
    Rodríguez-Soto AE, Pham D, Tran T, Meads M, Stanley V, Melber D, Lamale-Smith L, Zhang-Rutledge K, Rakow-Penner R, Alshawabkeh L, Parast MM, Contijoch F.
    Placenta. 2022 Jan;117:209-212. doi: 10.1016/j.placenta.2021.12.016. Epub 2021 Dec 18.

  22. Prevalence of Venovenous Shunting and High-Output State Quantified with 4D Flow MRI in Patients with Fontan Circulation
    Raimondi F, Martins D, Coenen R, Panaioli E, Khraiche D, Boddaert N, Bonnet D, Atkins M, El-Said H, Alshawabkeh L, Hsiao A.
    Radiol Cardiothorac Imaging. 2021 Dec 16;3(6):e210161. doi: 10.1148/ryct.210161. eCollection 2021 Dec.

  23. Methamphetamine-Associated Heart Failure Hospitalizations Across the United States: Geographic and Social Disparities
    Dickson SD, Thomas IC, Bhatia HS, Nishimura M, Mahmud E, Tu XM, Lin T, Adler E, Greenberg B, Alshawabkeh L.
    J Am Heart Assoc. 2021 Aug 17;10(16):e018370. doi: 10.1161/JAHA.120.018370. Epub 2021 Aug 7.

  24. COVID-19 in Adults With Congenital Heart Disease
    Broberg CS, Kovacs AH, Sadeghi S, Rosenbaum MS, Lewis MJ, Carazo MR, Rodriguez FH 3rd, Halpern DG, Feinberg J, Galilea FA, Baraona F, Cedars AM, Ko JM, Porayette P, Maldonado J, Sarubbi B, Fusco F, Frogoudaki AA, Nir A, Chaudhry A, John AS, Karbassi A, Hoskoppal AK, Frischhertz BP, Hendrickson B, Bouma BJ, Rodriguez-Monserrate CP, Broda CR, Tobler D, Gregg D, Martinez-Quintana E, Yeung E, Krieger EV, Ruperti-Repilado FJ, Giannakoulas G, Lui GK, Ephrem G, Singh HS, Almeneisi HM, Bartlett HL, Lindsay I, Grewal J, Nicolarsen J, Araujo JJ, Cramer JW, Bouchardy J, Al Najashi K, Ryan K, Alshawabkeh L, Andrade L, Ladouceur M, Schwerzmann M, Greutmann M, Meras P, Ferrero P, Dehghani P, Tung PP, Garcia-Orta R, Tompkins RO, Gendi SM, Cohen S, Klewer S, Hascoet S, Mohammadzadeh S, Upadhyay S, Fisher SD, Cook S, Cotts TB, Aboulhosn JA.
    J Am Coll Cardiol. 2021 Apr 6;77(13):1644-1655. doi: 10.1016/j.jacc.2021.02.023.

  25. 4D Flow MRI Quantification of Congenital Shunts: Comparison to Invasive Catheterization
    Horowitz MJ, Kupsky DF, El-Said HG, Alshawabkeh L, Kligerman SJ, Hsiao A.
    Radiol Cardiothorac Imaging. 2021 Apr 1;3(2):e200446. doi: 10.1148/ryct.2021200446. eCollection 2021 Apr.

  26. Percutaneous mitral valve repair in adults with congenital heart disease: Report of the first case-series
    Alshawabkeh L, Mahmud E, Reeves R.
    Catheter Cardiovasc Interv. 2021 Feb 15;97(3):542-548. doi: 10.1002/ccd.29238. Epub 2020 Sep 8.

  27. Single-Barrel, Double-Barrel, and Fenestrated Endografts to Facilitate Transcatheter Pulmonary Valve Replacement in Large RVOT
    Kamioka N, Babaliaros VC, Lisko JC, Sahu A, Shashidharan S, Carazo MR, Jokhadar M, Rodriguez FH 3rd, Book WM, Gleason PT, Keeling WB, Jaber W, Block PC, Lederman RJ, Greenbaum AB, Kim DW.
    JACC Cardiovasc Interv. 2020 Dec 14;13(23):2755-2765. doi: 10.1016/j.jcin.2020.08.024.

  28. Impact of Pregnancy on Ventricular Strain in Women with Repaired Tetralogy of Fallot
    Duarte VE, Graf JA, Gauvreau K, Easter SR, Drakeley SC, Carazo MR, Economy KE, Valente AM, Harrild DM.
    Pediatr Cardiol. 2020 Dec;41(8):1795-1799. doi: 10.1007/s00246-020-02447-3. Epub 2020 Sep 11.

  29. Assessment and management of heart failure in the systemic right ventricle
    Carazo M, Andrade L, Kim Y, Wilson W, Wu FM.
    Heart Fail Rev. 2020 Jul;25(4):609-621. doi: 10.1007/s10741-020-09914-2.

  30. Mechanisms for heart failure in systemic right ventricle
    Andrade L, Carazo M, Wu F, Kim Y, Wilson W.
    Heart Fail Rev. 2020 Jul;25(4):599-607. doi: 10.1007/s10741-019-09902-1.

  31. Prevalence and Prognostic Association of a Clinical Diagnosis of Depression in Adult Congenital Heart Disease: Results of the Boston Adult Congenital Heart Disease Biobank
    Carazo MR, Kolodziej MS, DeWitt ES, Kasparian NA, Newburger JW, Duarte VE, Singh MN, Opotowsky AR.
    J Am Heart Assoc. 2020 May 5;9(9):e014820. doi: 10.1161/JAHA.119.014820. Epub 2020 Apr 28.

  32. Significance of Aortopulmonary Collaterals in a Single-Ventricle Patient Supported With a HeartMate 3
    Smith M, El-Said H, Pretorius V, Mendenhall M, Thomas T, Reeves RR, Silva Enciso J, Alshawabkeh L, Nigro J, Adler ED, Urey MA.
    Circ Heart Fail. 2020 Apr;13(4):e006473. doi: 10.1161/CIRCHEARTFAILURE.119.006473. Epub 2020 Apr 6.

  33. Clinical Characteristics and Outcomes of Patients With Heart Failure and Methamphetamine Abuse
    Thomas IC, Nishimura M, Ma J, Dickson SD, Alshawabkeh L, Adler E, Maisel A, Criqui MH, Greenberg B.
    J Card Fail. 2020 Mar;26(3):202-209. doi: 10.1016/j.cardfail.2019.10.002. Epub 2019 Oct 13.

  34. The Impact of Substance Abuse on Heart Failure Hospitalizations
    Nishimura M, Bhatia H, Ma J, Dickson SD, Alshawabkeh L, Adler E, Maisel A, Criqui MH, Greenberg B, Thomas IC.
    Am J Med. 2020 Feb;133(2):207-213.e1. doi: 10.1016/j.amjmed.2019.07.017. Epub 2019 Jul 29.

  35. Creatinine versus cystatin C to estimate glomerular filtration rate in adults with congenital heart disease: Results of the Boston Adult Congenital Heart Disease Biobank
    Opotowsky AR, Carazo M, Singh MN, Dimopoulos K, Cardona-Estrada DA, Elantably A, Waikar SS, Mc Causland FR, Veldtman G, Grewal J, Gray C, Loukas BN, Rajpal S.
    Am Heart J. 2019 Aug;214:142-155. doi: 10.1016/j.ahj.2019.04.018. Epub 2019 May 22.

  36. Evaluation of Fontan liver disease: Correlation of transjugular liver biopsy with magnetic resonance and hemodynamics
    Silva-Sepulveda JA, Fonseca Y, Vodkin I, Vaughn G, Newbury R, Vavinskaya V, Dwek J, Perry JC, Reshamwala P, Baehling C, Lyon J, Davis C, Lee JW, El-Sabrout H, Shahbah D, Alshawabkeh L, Moore JW, El-Said H.
    Congenit Heart Dis. 2019 Jul;14(4):600-608. doi: 10.1111/chd.12770. Epub 2019 Apr 30.

  37. Contemporary ACHD training and the reality of the field in the United States
    Ephrem G, Alshawabkeh L.
    Int J Cardiol. 2019 Feb 15;277:85-89. doi: 10.1016/j.ijcard.2018.08.086. Epub 2018 Sep 1.

  38. Disparities in Wait-List Outcomes for Adults With Congenital Heart Disease Listed for Heart Transplantation Before and Since Revision of Status I Listing
    Alshawabkeh L, Opotowsky AR, Carter KD, Givertz MM, Landzberg MJ, Urey MA, Bartlett H.
    Am J Cardiol. 2018 Nov 15;122(10):1761-1764. doi: 10.1016/j.amjcard.2018.08.013. Epub 2018 Aug 21.

  39. Relationship of Red Cell Distribution Width to Adverse Outcomes in Adults With Congenital Heart Disease (from the Boston Adult Congenital Heart Biobank)
    Alshawabkeh L, Rajpal S, Landzberg MJ, Emani S, Ephrem G, Gray C, Singh MN, Wu F, Opotowsky AR.
    Am J Cardiol. 2018 Nov 1;122(9):1557-1564. doi: 10.1016/j.amjcard.2018.07.019. Epub 2018 Aug 3.

  40. Prospective cohort study of C-reactive protein as a predictor of clinical events in adults with congenital heart disease: results of the Boston adult congenital heart disease biobank
    Opotowsky AR, Valente AM, Alshawabkeh L, Cheng S, Bradley A, Rimm EB, Landzberg MJ.
    Eur Heart J. 2018 Sep 7;39(34):3253-3261. doi: 10.1093/eurheartj/ehy362.

  41. Association of Albuminuria With Major Adverse Outcomes in Adults With Congenital Heart Disease: Results From the Boston Adult Congenital Heart Biobank
    Rajpal S, Alshawabkeh L, Almaddah N, Joyce CM, Shafer K, Gurvitz M, Waikar SS, Mc Causland FR, Landzberg MJ, Opotowsky AR.
    JAMA Cardiol. 2018 Apr 1;3(4):308-316. doi: 10.1001/jamacardio.2018.0125.

  42. Thermodilution vs Estimated Fick Cardiac Output Measurement in Clinical Practice: An Analysis of Mortality From the Veterans Affairs Clinical Assessment, Reporting, and Tracking (VA CART) Program and Vanderbilt University
    Opotowsky AR, Hess E, Maron BA, Brittain EL, Barón AE, Maddox TM, Alshawabkeh LI, Wertheim BM, Xu M, Assad TR, Rich JD, Choudhary G, Tedford RJ.
    JAMA Cardiol. 2017 Oct 1;2(10):1090-1099. doi: 10.1001/jamacardio.2017.2945.

  43. Current Role of Blood and Urine Biomarkers in the Clinical Care of Adults with Congenital Heart Disease
    Rajpal S, Alshawabkeh L, Opotowsky AR.
    Curr Cardiol Rep. 2017 Jun;19(6):50. doi: 10.1007/s11886-017-0860-z.

  44. Prognostic Utility of the Braden Scale and the Morse Fall Scale in Hospitalized Patients With Heart Failure
    Carazo M, Sadarangani T, Natarajan S, Katz SD, Blaum C, Dickson VV.
    West J Nurs Res. 2017 Apr;39(4):507-523. doi: 10.1177/0193945916664077. Epub 2016 Aug 20.

  45. Anticoagulation During Pregnancy: Evolving Strategies With a Focus on Mechanical Valves
    Alshawabkeh L, Economy KE, Valente AM.
    J Am Coll Cardiol. 2016 Oct 18;68(16):1804-1813. doi: 10.1016/j.jacc.2016.06.076.

  46. Burden of Heart Failure in Adults with Congenital Heart Disease
    Alshawabkeh LI, Opotowsky AR.
    Curr Heart Fail Rep. 2016 Oct;13(5):247-254. doi: 10.1007/s11897-016-0301-0.

  47. Wait-List Outcomes for Adults With Congenital Heart Disease Listed for Heart Transplantation in the U.S
    Alshawabkeh LI, Hu N, Carter KD, Opotowsky AR, Light-McGroary K, Cavanaugh JE, Bartlett HL.
    J Am Coll Cardiol. 2016 Aug 30;68(9):908-17. doi: 10.1016/j.jacc.2016.05.082.

  48. Clinical pharmacology relevant to older adults with cardiovascular disease
    Brenes-Salazar JA, Alshawabkeh L, Schmader KE, Hanlon JT, Forman DE.
    J Geriatr Cardiol. 2015 May;12(3):192-5. doi: 10.11909/j.issn.1671-5411.2015.03.018.

  49. Expanding pseudoaneurysm compressing the coronary arteries and causing cardiogenic shock
    Maliske SM, Alshawabkeh L, Schouweiler K, Sigurdsson G.
    J Cardiovasc Comput Tomogr. 2015 May-Jun;9(3):230-1. doi: 10.1016/j.jcct.2014.12.003. Epub 2014 Dec 26.

  50. Years of able life in older persons--the role of cardiovascular imaging and biomarkers: the Cardiovascular Health Study
    Alshawabkeh LI, Yee LM, Gardin JM, Gottdiener JS, Odden MC, Bartz TM, Arnold AM, Mukamal KJ, Wallace RB.
    J Am Heart Assoc. 2015 Apr 23;4(4):e001745. doi: 10.1161/JAHA.114.001745.

  51. Outcomes of a preoperative "bridging" strategy with glycoprotein IIb/IIIa inhibitors to prevent perioperative stent thrombosis in patients with drug-eluting stents who undergo surgery necessitating interruption of thienopyridine administration
    Alshawabkeh LI, Prasad A, Lenkovsky F, Makary LF, Kandil ES, Weideman RA, Kelly KC, Rangan BV, Banerjee S, Brilakis ES.
    EuroIntervention. 2013 Jun 22;9(2):204-11. doi: 10.4244/EIJV9I2A35.

  52. Systematic review of the frequency and outcomes of non-cardiac surgery after drug-eluting stent implantation
    Alshawabkeh LI, Banerjee S, Brilakis ES.
    Hellenic J Cardiol. 2011 Mar-Apr;52(2):141-8.