Stephan Lange, PhD
Dr. Lange's research interests are to investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. The work in his laboratory is specifically geared towards the identification of molecular origins and pathways associated with the development and progression of human cardiomyopathies and muscular dystrophies.
Dr. Lange trained at the Humboldt University in Berlin, Germany, the Institute for Cell Biology at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland, and the Randall and Cardiovascular Divisions at King's College London, United Kingdom, before joining UC San Diego in 2007. His research resulted in numerous publications in top journals. In addition, Dr. Lange received several awards in recognition of his scientific work.
Dr. Lange's work is currently funded by a grant from the National Institutes of Health.
Dr. Lange's laboratory investigates the development and function of heart and skeletal muscles. The research focus is centered on the identification of molecular origins and pathways that lead to the development of cardiomyopathies and muscular dystrophies. We are particularly interested how mutations in sarcomeric and muscle associated proteins lead to the development of these diseases.
Below is a list of key publications exemplary of Dr. Lange's work. Please visit his laboratory website for a full list of publications.
The kinase domain of titin controls muscle gene expression and protein turnover. Lange S*, Xiang F*, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M. Science. 2005 Jun 10;308(5728):1599-603.
From A to Z and back? Multicompartment proteins in the sarcomere. Lange S, Ehler E, Gautel M. Trends Cell Biol. 2006 Jan;16(1):11-8.
Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. Fukuzawa A*, Lange S*, Holt M, Vihola A, Carmignac V, Ferreiro A, Udd B, Gautel M. J Cell Sci. 2008 Jun 1;121(Pt 11):1841-51.
Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. Lange S*, Ouyang K*, Meyer G, Cui L, Cheng H, Lieber RL, Chen J. J Cell Sci. 2009 Aug 1;122(Pt 15):2640-50.
Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Lange S, Perera S, Teh P, Chen J. Mol Biol Cell. 2012 Jul;23(13):2490-504.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. Raskin A*, Lange S*, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. J Biol Chem. 2012 Aug 24;287(35):29273-84.