Robert S. Ross, M.D. 

Professor of Medicine
Director, Echocardiography Lab, VA San Diego



Contact Information

VA San Diego Healthcare System
3350 La Jolla Village Drive
Cardiology Section, 111A
San Diego, California 92161
Phone: (858) 642-1138
Fax: (858) 642-1199
E-mail:  rross@ucsd.edu

General Cardiology, Echocardiography, Adult Congenital Heart Disease

Communication between cells and their surrounding support structures plays a crucial role as organs develop and grow. My laboratory is interested in studying how the cardiac myocyte interacts with the extracellular matrix as the heart undergoes postnatal pathological growth or develops in the embryo. Our group utilizes a combination of molecular biological techniques and physiological analyses, along with cell culture, transgenic and knockout mouse models, to study this process. The current principal focus of the lab involves the study of integrins and integrin associated proteins, as signaling and cell-adhesive molecules in the heart.

Recent Publications

  • Inubushi M, Jordan MC, Roos KP, Ross RS, Chatziioannou AF, Stout DB, Dahlbom M, Schelbert HR. Nitrogen-13 ammonia cardiac positron emission tomography in mice: effects of clonidine-induced changes in cardiac work on myocardial perfusion. Eur J Nucl Med Mol Imaging. 2004 Jan;31(1):110-6.
  • Willey CD, Balasubramanian S, Rodriguez Rosas MC, Ross RS, Kuppuswamy D. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. J Mol Cell Cardiol. 2003 Jun;35(6):671-83.
  • Reuter H, Henderson SA, Han T, Mottino GA, Frank JS, Ross RS, Goldhaber JI, Philipson KD. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium. 2003 Jul;34(1):19-26.
  • Collins AR, Schnee J, Wang W, Kim S, Fishbein MC, Breummer D, Law RE, Nicholas S, Ross RS, Hsueh WA. Osteopontin mediates angiotensin II-induced cardiac fibrosis in the intact murine heart. J Am Coll Cardiol. 2004 May 5;43(9):1698-1705.
  • Cheng Q, Ross RS, Walsh KB. Overexpression of the integrin 1A subunit and the 1A cytoplasmic domain modifies the -adrenergic regulation of the cardiac L-type calcium current. J Mol Cell Cardiol. 2004 Jun; 36(6):809-19.
  • Zemljič-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross RS. Heterozygous inactivation of the vinculin gene predisposes to stress induced cardiomyopathy. Am Jnl Pathology 2004 Sept 165(3)1033-1044.
  • Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, Chantawansri C, Ritter MR, Friedlander M, Nicoll DA, Frank JS, Jordan MC, Roos KP, Ross RS, Philipson KD. Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res. 2004 Sep 17;95(6):604-11.

Book Chapters, Editorials and Invited Reviews

  • Ross RS: Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors. Cardiovasc Res 2004, 63: 381-390
  • Ross RS: Cardiac remodeling: is 8 the heart's lucky number? J Mol Cell Cardiol 2004, 36: 323-3