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Professor of Medicine
Chief, Division of Cardiology |
Division Office:
UCSD Medical Center
200 W. Arbor Drive, #8411
San Diego, CA 92103-8411
ph (619)471-9040
kknowlton@ucsd.edu
Research Office:
9500 Gilman Drive
La Jolla, CA 92037-0613K
Phone: (858) 822-1364
Fax: (858) 822-3027
Research Interests
Molecular mechanisms of viral heart disease and cardiomyopathies, as well as regulation of cardiac gene expression during ventricular hypertrophy and failure.
Clinical Interests
Pulmonary hypertension, echocardiography
Recent Publications
Kim NHS, Fesler P, Channick RN, Knowlton KU, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. Pre-operative measurements of pulmonary artery occlusion pressure correlate with early outcome following thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation, 109:18-22, 2004.
Dorner A, Xiong D, Couch K, Yajima T, Knowlton KU. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. Journal of Biological Chemistry, 279:18497-18503, 2004.
Knowlton KU, Yajima T. Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis? Journal of the American College of Cardiology, 44:1298-1300, 2004.
Auger WR, Kerr KM, Kim NH, Ben-Yehuda O, Knowlton KU, Fedulo PF. Chronic thrombo-embolic pulmonary hypertension. Cardiol. Clin. 22:453-466 (2004).
Lim BK, Shin JO, Lee SC, Kim DK, Choi DJ, Choe SC, Knowlton KU, Jeon ES. Long-term cardiac gene expression using a coxsackieviral vector. Journal of Molecular and Cellular Cardiology. 38:745-751 (2005).
Dorner A., Grunert HP, Lindig V, Chandrasekharan K, Fechner H, Knowlton KU, Isik A, Pauschinger M, Zeichhardt H, Schultheiss HP. Treatment of coxsackievirus B3-infected BALOB/c mice with the soluble coxsackie adenovirus receptor CAR4/7 aggravates cardiac injury. Journal of Molecular Medicine, 84:842-851 (2006).
Bang ML. Li X, Littlefield R, Bremner S, Thor A, Knowlton KU, Lieber RL, Chen J, Nebulindeficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 173:905-916 (2006).
Trifilo MJ, Yajima T, Gu Y, Peterson KL, Race RE, Meade-White K, Masliah E, Knowlton K, Chesebro B, Oldstone BA. Prion-Induced amyloid heart disease with high blood infectivity. Science 313:94-97 (2006).
Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M. Chien KR, Yoshimura A, Knowlton KU. An Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 114:2364-2373 (2006).
Sheikh F, Chen Y, Loang X, Hirschy A, Stenbit AE, Gu Y, Dalton MD, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC and Chen J. Alpha-E-catenin Inactivation disrupts the cardiomyocyte adherens junction resulting in cardiomyopathy and susceptibility to wall rupture. Circulation, 114:1046-1055 (2006).
Xiong D, Yajima T, Stenbit A, Lim BK, Dublin A, Dalton N, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Knowlton KU. Cardiac Restricted, Inducible Expression of Enteroviral Protease 2A is Sufficient to Induce Dilated. Circulation, 115:000-000 (2007).
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